New research indicates that individuals who stop using popular slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who halt conventional lifestyle regimens.
Findings released in a prominent medical journal demonstrates that while obese people frequently drop a large proportion of their total mass while on the medication, the weight comes back at an estimated rate of nearly a kilo each month once they quit.
"People purchasing these medications should be cognizant of the danger of fast rebound weight gain when the medication is stopped," warns lead investigator Dr. Susan Jebb.
Such speed of regain implies a return to pre-treatment weight within about one and a half years.
Analyzing Treatments
The analysis, which examined 37 of trials involving over 9,000 of participants, contrasted the results of these new drugs with other pills.
Scientists point out that people who shed pounds through dieting generally have a slower creep back—perhaps 0.1 kg a month—once they finish.
Explaining the Quick Regain
Nutrition scientists believe the mechanism of the injections is key to understanding the heightened rebound.
GLP-1 drugs imitate a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 concentrations several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous GLP-1, and may also diminish sensitivity to its effects," explained Dr. Adam Collins, a dietetics expert.
"Stopping of this hormone supplement means hunger is unsuppressed, making binge eating a significant risk."
An Ongoing Issue?
Health authorities recommend the jabs for people with obesity-related health risks, alongside prescribed diet and exercise modifications.
Professionals argue that, given the likelihood of weight regain, the therapy is often ongoing.
This opinion is echoed by pharmaceutical companies, who note that the findings "emphasize the persistent nature of obesity," akin to managing conditions like diabetes.
Patient Experiences
Users who have stopped the jabs report a sudden resurgence of hunger.
"It felt as if a trigger activating and I was suddenly extremely hungry," described a patient.
The struggle is worsened if patients have not established lasting dietary or behavioural changes during treatment.
Widespread Use
Recent estimates suggest that millions of people in the UK have used these injections in the past year, with interest remaining high.
- Adoption is greater among females compared to males.
- The 40s and 50s demographic shows the highest level of interest.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while these medications are potent agents for weight loss, they are not a permanent cure and lasting health benefits relies on integrated lifestyle changes.
