British Air Force Typhoon jets have joined forces with French aircraft in a combined operation targeting an subterranean weapons facility in Syria operated by the IS group, according to the UK's MoD.
The site, located using reconnaissance, was assessed as containing munitions and bombs, the announcement noted, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"Our fighter planes used laser-guided Paveway IV weapons to strike a series of access tunnels leading to the facility... early reports are that the target was engaged successfully," the MoD said.
There was no indication of any civilian casualties in the operation on Saturday evening and each participating jet returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
IS - referred to as ISIS - imposed militant control over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows our UK leadership, and determination to work closely with allied nations, to eliminate any revival of the terrorist group and their violent and radical beliefs in the Middle East," Britain's Defence Chief the minister said.
British military aircraft have conducted overwatch operations over Syria to "deter any attempted comeback" of Islamic State subsequent to its routing at the Baghuz confrontation in 2019, the authorities noted.
"I want to thank every member of British forces who took part in this mission for their professionalism and their valour," the Defence Secretary added. "Including them were numerous British personnel stationed over Christmas and New Year. This mission, to take out dangerous terrorists who threaten our way of life, highlights how our armed forces are always on standby, continuously, ensuring Britain's security within its borders and influential overseas."
Last December, the US military carried out what it termed a "massive strike" on Islamic State objectives in the country, after an assault claimed the lives of two US servicemembers and a civilian linguist in the Palmyra area.
The UN reports Daesh still has roughly 5-7 thousand fighters in Iraq and Syria.